Associations between Nonalcoholic Fatty Liver Disease and Histopathological Features of Patients with Adenocarcinoma of Colon in Dharmais National Cancer Hospital, National Cancer Center, Indonesia

Abstract

Objective: Previous studies have suggested that non-alcoholic fatty liver disease (NAFLD) may be a risk factor for colon cancer and that there was a high prevalence of colon cancer patients with NAFLD. This study aimed to determine the prevalence of fatty liver in colon adenocarcinoma patients in Dharmais National Cancer Hospital, Indonesia, and its associations with grading and extend of invasion. Methods: The retrospective cross-sectional study was conducted in Dharmais National Cancer Hospital, Indonesia. The diagnosis of adenocarcinoma of colon was confirmed by histopathology. The cases from 2018-2019 were studied. All variables taken from medical records were anthropometric measures, ALT, AST, grading, and extend of invasion of adenocarcinoma. The liver of the Patients’ was assessed with Hepatic Steatosis Index (HSI) scoring. The data was computed statistically with the chi-square test or Kolmogorov Smirnov test. Result: 84 patients were included in the study. It was found that 14.3% of the patients have fatty liver. Bivariate analysis showed that HSI groups and well-differentiated and moderate-poor-differentiated adenocarcinoma have the p-value of 0,026. The p-value of HSI groups and extend of invasion of the adenocarcinoma was 1. Conclusion: The prevalence of fatty liver in patients who had adenocarcinoma of colon was 14.3%. There was an association between fatty liver and grading. There was no association between fatty liver and the extend of invasion.

Keywords

• colon adenocarcinoma, fatty liver, nafld