Coluna/Columna ()

GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW

  • RICARDO VIEIRA TELES FILHO,
  • GUILHERME DE MATOS ABE,
  • NILO CARRIJO MELO,
  • MARCELO FOUAD RABAHI,
  • MURILO TAVARES DAHER

DOI
https://doi.org/10.1590/s1808-185120191803212974
Journal volume & issue
Vol. 18, no. 3
pp. 236 – 239

Abstract

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ABSTRACT The idiopathic scoliosis (IS) is the most common form of spinal deformity. The pathogenesis of IS is still poorly understood. Several studies show evidence that the genetic component is determinant to the development of IS. In this setting, a crescent focus has been placed on the identification of genes, associated genetic polymorphisms, and multiple susceptibility loci. This review highlights the genes and genetic polymorphisms currently studied, identified as influential in the genesis of IS, such as MMP-3, IL-6, type I collagen, and vitamin D and estrogen receptors. We concluded that IS remains a complex disease with a polygenic background and that genetic polymorphisms are intrinsically related to this condition. Level of evidence III; Narrative Review.

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