Association between the immune-inflammation indicators and osteoarthritis - NHANES 1999–2018

Yan Xue; Cheng Chang; Yajun Chen; Lang Jia; Han Wang; Zaoyang Liu; Jiang Xie

Osteoarthritis and Cartilage Open (Mar 2025)

Association between the immune-inflammation indicators and osteoarthritis - NHANES 1999–2018

Yan Xue,
Cheng Chang,
Yajun Chen,
Lang Jia,
Han Wang,
Zaoyang Liu,
Jiang Xie

Affiliations

Yan Xue: Department of Pediatrics, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, Sichuan, China; Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China
Cheng Chang: Department of Cardiothoracic Surgery, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu 610014, China; Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China
Yajun Chen: Department of Pediatrics, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, Sichuan, China; North Sichuan Medical College, Nanchong 637100, China
Lang Jia: Department of Pediatrics, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, Sichuan, China; School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China
Han Wang: Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu 610014, China
Zaoyang Liu: Department of Cardiothoracic Surgery, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu 610014, China
Jiang Xie: Department of Pediatrics, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, Sichuan, China; Corresponding author. The Third People's Hospital of Chengdu, Sichuan, 610031, China.

Journal volume & issue: Vol. 7, no. 1
p. 100453

Abstract

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Background: Investigate the link between systemic immune-inflammatory index (SII) and Systemic Immune Response Index (SIRI) with osteoarthritis (OA) using National Health and Nutrition Examination Survey (NHANES) data (1999–2018). Methods: Extracted NHANES data (1999–2018) and selected a study population based on demographic, examination, and laboratory data. Calculated SII (platelet count × neutrophil count/lymphocyte count) and SIRI (neutrophil count × monocyte count/lymphocyte count). Employed multivariate logistic regression and restricted cubic spline (RCS) regression for Ln-SII, SIRI, and OA relationship investigation. Conducted subgroup analyses. Results: Study involved 32,144 participants (16,515 males, 15,629 females), with 12.16% having OA. Positive correlation between highest SII quartile and OA in unadjusted and adjusted model 1 (Unadjusted Model, P 0.05). Conclusion: When SII exceeds 595.86, OA prevalence may rise. Besides, there was a significant positive correlation between SIRI and OA prevalence. SII and SIRI may be useful markers for OA research, warranting further exploration in this area.

Published in Osteoarthritis and Cartilage Open

ISSN: 2665-9131 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the musculoskeletal system
Website: https://www.journals.elsevier.com/osteoarthritis-and-cartilage-open/

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