Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

Eszter Paldy; Manuela Simonetti; Thomas Worzfeld; Kiran Kumar Bali; Lucas Vicuña; Stefan Offermanns; Rohini Kuner

doi:10.1038/s41467-017-00341-w

Nature Communications (Aug 2017)

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

Eszter Paldy,
Manuela Simonetti,
Thomas Worzfeld,
Kiran Kumar Bali,
Lucas Vicuña,
Stefan Offermanns,
Rohini Kuner

Affiliations

Eszter Paldy: Institute of Pharmacology, Heidelberg University
Manuela Simonetti: Institute of Pharmacology, Heidelberg University
Thomas Worzfeld: Institute of Pharmacology, Marburg University
Kiran Kumar Bali: Institute of Pharmacology, Heidelberg University
Lucas Vicuña: Institute of Pharmacology, Heidelberg University
Stefan Offermanns: Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research
Rohini Kuner: Institute of Pharmacology, Heidelberg University

DOI: https://doi.org/10.1038/s41467-017-00341-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Semaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronociceptive in a mouse model of inflammatory pain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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