Nature Communications (Jun 2022)

Host lung microbiota promotes malaria-associated acute respiratory distress syndrome

  • Debanjan Mukherjee,
  • Ângelo Ferreira Chora,
  • Jean-Christophe Lone,
  • Ricardo S. Ramiro,
  • Birte Blankenhaus,
  • Karine Serre,
  • Mário Ramirez,
  • Isabel Gordo,
  • Marc Veldhoen,
  • Patrick Varga-Weisz,
  • Maria M. Mota

DOI
https://doi.org/10.1038/s41467-022-31301-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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The reasons why malaria manifests with a variety of well-recognized clinical phenotypes remain poorly understood. Here, using distinct rodent models, the authors reveal that the microbiota colonizing the lung promotes respiratory distress syndrome and mortality during malaria infections.