Type-2 Diabetes remains a progressive chronic disease that takes more and more lives every year. Small studies are beginning to show that a lifestyle approach could reverse type-2 diabetes in most individuals. The key discoveries from these studies are captured and formulated into a System Design Map for Prevention, Early Detection, and Reversal of Type-2 Diabetes using Collective System Design. Collective System Design describes systems as four aspects that interrelate: tone, thinking, structure and work. The tone in Collective System Design fosters an environment that views human failure as a failure of the system design itself. The thinking in Collective System Design is communicated by Axiomatic Design (AD).With the Collective System Design Approach, a model for prevention, early detection, and reversal of chronic disease is developed. The motivation for this paper is the ability to save millions of lives through a sustainable lifestyle program by identifying the required diet and exercise.