Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33

Michael A. Schumacher; Jonathan J. Hsieh; Cambrian Y. Liu; Keren L. Appel; Amanda Waddell; Dana Almohazey; Kay Katada; Jessica K. Bernard; Edie B. Bucar; Safina Gadeock; Kathryn M. Maselli; M. Kay Washington; Tracy C. Grikscheit; David Warburton; Michael J. Rosen; Mark R. Frey

doi:10.1038/s41467-021-21113-7

Nature Communications (Feb 2021)

Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33

Michael A. Schumacher,
Jonathan J. Hsieh,
Cambrian Y. Liu,
Keren L. Appel,
Amanda Waddell,
Dana Almohazey,
Kay Katada,
Jessica K. Bernard,
Edie B. Bucar,
Safina Gadeock,
Kathryn M. Maselli,
M. Kay Washington,
Tracy C. Grikscheit,
David Warburton,
Michael J. Rosen,
Mark R. Frey

Affiliations

Michael A. Schumacher: The Saban Research Institute, Children’s Hospital Los Angeles
Jonathan J. Hsieh: The Saban Research Institute, Children’s Hospital Los Angeles
Cambrian Y. Liu: The Saban Research Institute, Children’s Hospital Los Angeles
Keren L. Appel: The Saban Research Institute, Children’s Hospital Los Angeles
Amanda Waddell: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center
Dana Almohazey: Department of Stem Cell Research, Institute for Research and Medical Consultation (IRMC), Imam Abdulrahman Bin Faisal University
Kay Katada: The Saban Research Institute, Children’s Hospital Los Angeles
Jessica K. Bernard: The Saban Research Institute, Children’s Hospital Los Angeles
Edie B. Bucar: The Saban Research Institute, Children’s Hospital Los Angeles
Safina Gadeock: The Saban Research Institute, Children’s Hospital Los Angeles
Kathryn M. Maselli: The Saban Research Institute, Children’s Hospital Los Angeles
M. Kay Washington: Departments of Pathology, Microbiology, and Immunology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center
Tracy C. Grikscheit: The Saban Research Institute, Children’s Hospital Los Angeles
David Warburton: The Saban Research Institute, Children’s Hospital Los Angeles
Michael J. Rosen: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center
Mark R. Frey: The Saban Research Institute, Children’s Hospital Los Angeles

DOI: https://doi.org/10.1038/s41467-021-21113-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Dynamic regulation of colonic secretory cell numbers is a critical component of the response to intestinal injury and inflammation. Here, the authors show that loss of the intracellular signalling regulator Sprouty2 in the intestinal epithelial cells is a protective response to injury that leads to increased secretory cell numbers, thus limiting colitis severity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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