Nature Communications (Feb 2023)
Malaria-driven adaptation of MHC class I in wild bonobo populations
- Emily E. Wroblewski,
- Lisbeth A. Guethlein,
- Aaron G. Anderson,
- Weimin Liu,
- Yingying Li,
- Sara E. Heisel,
- Andrew Jesse Connell,
- Jean-Bosco N. Ndjango,
- Paco Bertolani,
- John A. Hart,
- Terese B. Hart,
- Crickette M. Sanz,
- David B. Morgan,
- Martine Peeters,
- Paul M. Sharp,
- Beatrice H. Hahn,
- Peter Parham
Affiliations
- Emily E. Wroblewski
- Department of Anthropology, Washington University in St. Louis
- Lisbeth A. Guethlein
- Department of Structural Biology, Stanford University School of Medicine
- Aaron G. Anderson
- Department of Anthropology, Washington University in St. Louis
- Weimin Liu
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Yingying Li
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Sara E. Heisel
- Department of Anthropology, Washington University in St. Louis
- Andrew Jesse Connell
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Jean-Bosco N. Ndjango
- Department of Ecology and Management of Plant and Animal Resources, Faculty of Sciences, University of Kisangani
- Paco Bertolani
- Institute of Human Sciences, School of Anthropology and Museum Ethnography, University of Oxford
- John A. Hart
- Frankfurt Zoological Society, Lomami National Park Project
- Terese B. Hart
- Frankfurt Zoological Society, Lomami National Park Project
- Crickette M. Sanz
- Department of Anthropology, Washington University in St. Louis
- David B. Morgan
- Lester E. Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo
- Martine Peeters
- Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM
- Paul M. Sharp
- Institute of Ecology and Evolution, University of Edinburgh
- Beatrice H. Hahn
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Peter Parham
- Department of Structural Biology, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36623-9
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 11
Abstract
A variant of MHC class I is protective against severe malaria disease and enriched in affected African populations. Here, Wroblewski et al., characterise the consequences of malaria infection in wild bonobo populations showing that the presence of malaria drives a similar evolution in immune genes.
