Cherubism in sub-Saharan Africa: a first case-report in a child
Michel Ntetani Aloni,
Renault Sitwaminya Kambere,
Antoine Molua,
Joseph Nzinga Dilu,
Pierre Manianga Tshibassu,
Aimé Kazadi-Lukusa,
René Makuala Ngiyulu,
Raphael Mbona Kalengayi,
Jean Lambert Gini Ehungu
Affiliations
Michel Ntetani Aloni
Division of Pediatric Hemato-Oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, School of Medicine, University Hospital of Kinshasa, University of Kinshasa
Renault Sitwaminya Kambere
Department of Pathology, University Hospital of Kinshasa, School of Medicine, University Hospital of Kinshasa, University of Kinshasa
Antoine Molua
Department of Radiolology, University Hospital of Kinshasa, School of Medicine, University Hospital of Kinshasa, University of Kinshasa
Joseph Nzinga Dilu
Department of Stomatology and Maxillofacial Surgery, University Hospital of Kinshasa, School of Medicine, University Hospital of Kinshasa, University of Kinshasa
Pierre Manianga Tshibassu
Division of Gastroenterology and Neurology, Department of Pediatrics, University Hospital of Kinshasa, School of Medicine, University Hospital of Kinshasa, University of Kinshasa
Aimé Kazadi-Lukusa
Division of Pediatric Hemato-Oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, School of Medicine, University Hospital of Kinshasa, University of Kinshasa
René Makuala Ngiyulu
Division of Pediatric Hemato-Oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, School of Medicine, University Hospital of Kinshasa, University of Kinshasa
Raphael Mbona Kalengayi
Department of Pathology, University Hospital of Kinshasa, School of Medicine, University Hospital of Kinshasa, University of Kinshasa
Jean Lambert Gini Ehungu
Division of Pediatric Hemato-Oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, School of Medicine, University Hospital of Kinshasa, University of Kinshasa
Cherubism is rare disease and has been rarely reported in African pediatric population. We report here the case of a 10-year-old child who was referred to our hospital for bilateral jaws swelling. Physical examination revealed bilateral swelling symmetry of the face. Histopathological examination of the biopsy specimen showed loose fibrous stroma, proliferating fibrous connective with tissue interspersed with multinucleated giant cells, small thin walled blood vessels and scattered sparse mononuclear inflammatory infiltrate. Our patient presented cherubism. Cherubism is rarely described in children living in sub-Saharan Africa. Genetic and molecular investigations plays an important role in diagnosis but were not available in poor resources settings in developing countries such as the Democratic Republic of Congo.
