Sequential drug release via chemical diffusion and physical barriers enabled by hollow multishelled structures

Decai Zhao; Nailiang Yang; Yan Wei; Quan Jin; Yanlei Wang; Hongyan He; Yang Yang; Bing Han; Suojiang Zhang; Dan Wang

doi:10.1038/s41467-020-18177-2

Nature Communications (Sep 2020)

Sequential drug release via chemical diffusion and physical barriers enabled by hollow multishelled structures

Decai Zhao,
Nailiang Yang,
Yan Wei,
Quan Jin,
Yanlei Wang,
Hongyan He,
Yang Yang,
Bing Han,
Suojiang Zhang,
Dan Wang

Affiliations

Decai Zhao: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Nailiang Yang: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Yan Wei: Department of Geriatric Dentistry, NMPA Key Laboratory for Dental Materials, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Laboratory of Biomedical Materials, Peking University School and Hospital of Stomatology, Peking University
Quan Jin: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Yanlei Wang: Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Hongyan He: Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Yang Yang: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Institute for Advanced Study, Tongji University
Bing Han: Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, Peking University
Suojiang Zhang: Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Dan Wang: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-020-18177-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 7

Abstract

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Hollow multishell structures (HoMSs) consist of multiple shells with voids between them that provide separate reaction environments within the same assembly. Here, the authors used TiO2-HoMS to deliver a broad-spectrum antibacterial agent, in three-stages and in response to environmental changes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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