Frontiers in Pharmacology (Sep 2020)

Sanqi Oral Solution Ameliorates Renal Ischemia/Reperfusion Injury via Reducing Apoptosis and Enhancing Autophagy: Involvement of ERK/mTOR Pathways

  • Ruimin Tian,
  • Ruimin Tian,
  • Ruimin Tian,
  • Ruimin Tian,
  • Ruimin Tian,
  • Pinchao Wang,
  • Pinchao Wang,
  • Lihua Huang,
  • Lihua Huang,
  • Lihua Huang,
  • Lihua Huang,
  • Chuang Li,
  • Chuang Li,
  • Chuang Li,
  • Chuang Li,
  • Chuang Li,
  • Zhaoyu Lu,
  • Zhaoyu Lu,
  • Zhaoyu Lu,
  • Zhaoyu Lu,
  • Zhisheng Lu,
  • Zhisheng Lu,
  • Aijun Wu,
  • Aijun Wu,
  • Kun Bao,
  • Kun Bao,
  • Kun Bao,
  • Kun Bao,
  • Wei Mao,
  • Wei Mao,
  • Wei Mao,
  • Wei Mao,
  • Qingming Huang,
  • Qingming Huang,
  • Peng Xu,
  • Peng Xu,
  • Peng Xu,
  • Peng Xu,
  • Peng Xu

DOI
https://doi.org/10.3389/fphar.2020.537147
Journal volume & issue
Vol. 11

Abstract

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Ischemia-reperfusion (I/R) induced acute kidney injury (AKI) is a significant health problem with high morbidity and mortality, yet prophylaxis strategies and effective drugs are limited. Sanqi oral solution (SQ) is a formulated medicine widely used in clinical settings to treat various renal diseases via enriching qi and activating blood circulation while its role on I/R-AKI remains unclear. Herein, by establishing rat I/R-AKI models, we intended to investigate the effect of SQ on the prevention of I/R-AKI and explore its underlying mechanisms. We demonstrated that SQ treatment significantly attenuated renal dysfunction of I/R-AKI, alleviated histological damages, inhibited renal apoptosis, and enhanced autophagy. Further investigation proved that SQ could significantly inhibit the activation of ERK and mTOR signaling pathways. Moreover, its renoprotective effect can be abolished by autophagy inhibitor 3-methyladenine (3-MA). Collectively, our results suggest that SQ exerts renoprotective effects on renal I/R injury via reducing apoptosis and enhancing autophagy, which are associated with regulating ERK/mTOR pathways.

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