Frontiers in Pharmacology (Sep 2020)
Sanqi Oral Solution Ameliorates Renal Ischemia/Reperfusion Injury via Reducing Apoptosis and Enhancing Autophagy: Involvement of ERK/mTOR Pathways
- Ruimin Tian,
- Ruimin Tian,
- Ruimin Tian,
- Ruimin Tian,
- Ruimin Tian,
- Pinchao Wang,
- Pinchao Wang,
- Lihua Huang,
- Lihua Huang,
- Lihua Huang,
- Lihua Huang,
- Chuang Li,
- Chuang Li,
- Chuang Li,
- Chuang Li,
- Chuang Li,
- Zhaoyu Lu,
- Zhaoyu Lu,
- Zhaoyu Lu,
- Zhaoyu Lu,
- Zhisheng Lu,
- Zhisheng Lu,
- Aijun Wu,
- Aijun Wu,
- Kun Bao,
- Kun Bao,
- Kun Bao,
- Kun Bao,
- Wei Mao,
- Wei Mao,
- Wei Mao,
- Wei Mao,
- Qingming Huang,
- Qingming Huang,
- Peng Xu,
- Peng Xu,
- Peng Xu,
- Peng Xu,
- Peng Xu
Affiliations
- Ruimin Tian
- State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Ruimin Tian
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Ruimin Tian
- Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Ruimin Tian
- Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
- Ruimin Tian
- Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangzhou, China
- Pinchao Wang
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Pinchao Wang
- Department of Pediatrics, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Lihua Huang
- State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Lihua Huang
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Lihua Huang
- Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Lihua Huang
- Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
- Chuang Li
- State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Chuang Li
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Chuang Li
- Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Chuang Li
- Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
- Chuang Li
- Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangzhou, China
- Zhaoyu Lu
- State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Zhaoyu Lu
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Zhaoyu Lu
- Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Zhaoyu Lu
- Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
- Zhisheng Lu
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Zhisheng Lu
- Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Aijun Wu
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Aijun Wu
- Department of Pediatrics, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Kun Bao
- State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Kun Bao
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Kun Bao
- Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Kun Bao
- Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangzhou, China
- Wei Mao
- State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Wei Mao
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Wei Mao
- Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Wei Mao
- Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
- Qingming Huang
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Qingming Huang
- Department of Pediatrics, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Peng Xu
- State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Peng Xu
- The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- Peng Xu
- Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Peng Xu
- Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
- Peng Xu
- Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangzhou, China
- DOI
- https://doi.org/10.3389/fphar.2020.537147
- Journal volume & issue
-
Vol. 11
Abstract
Ischemia-reperfusion (I/R) induced acute kidney injury (AKI) is a significant health problem with high morbidity and mortality, yet prophylaxis strategies and effective drugs are limited. Sanqi oral solution (SQ) is a formulated medicine widely used in clinical settings to treat various renal diseases via enriching qi and activating blood circulation while its role on I/R-AKI remains unclear. Herein, by establishing rat I/R-AKI models, we intended to investigate the effect of SQ on the prevention of I/R-AKI and explore its underlying mechanisms. We demonstrated that SQ treatment significantly attenuated renal dysfunction of I/R-AKI, alleviated histological damages, inhibited renal apoptosis, and enhanced autophagy. Further investigation proved that SQ could significantly inhibit the activation of ERK and mTOR signaling pathways. Moreover, its renoprotective effect can be abolished by autophagy inhibitor 3-methyladenine (3-MA). Collectively, our results suggest that SQ exerts renoprotective effects on renal I/R injury via reducing apoptosis and enhancing autophagy, which are associated with regulating ERK/mTOR pathways.
Keywords
- renal ischemia-reperfusion (I/R)
- acute kidney injury (AKI)
- Radix Astragali
- Radix Notoginseng
- apoptosis
- autophagy