Association of Breast Cancer and In situ expression of Interleukin-4 (IL-4) and IL-10.

Abstract

Estimation of the in situ hybridization expression of IL-4and IL-10 in patients with malignant breast cancer. A technique utilizing in situ hybridization (ISH) was performed to detect and determine the in situ expression of IL-4 and IL-10 mRNA using paraffin embedded sections .Samples obtained from archive of department of pathology of two hospitals in Baghdad for 60 patients, who were divided into two groups: 30 with malignant breast cancer (group-1) and 30 woman with nonmalignant as a control group (group-2). The levels of the in situ expression of both IL-4 and IL-10 mRNA were found to be a highly significant increased in group 1 as compared with group 2 (p0.05) in all studied group. The increasing expression of IL-4 and IL-10 in malignant breast cancer tissue might be influence in the pathogenesis of malignant breast cancer.