Journal of the International Society of Sports Nutrition (Dec 2025)

International Society of Sports Nutrition Position Stand: Long-Chain Omega-3 Polyunsaturated Fatty Acids

  • Ralf Jäger,
  • Jeffery L. Heileson,
  • Sidney Abou Sawan,
  • Broderick L. Dickerson,
  • Megan Leonard,
  • Richard B. Kreider,
  • Chad M. Kerksick,
  • Stephen M. Cornish,
  • Darren G. Candow,
  • Dean M. Cordingley,
  • Scott C. Forbes,
  • Grant M. Tinsley,
  • Tindaro Bongiovanni,
  • Roberto Cannataro,
  • Bill I. Campbell,
  • Shawn M. Arent,
  • Jeffrey R. Stout,
  • Douglas S. Kalman,
  • Jose Antonio

DOI
https://doi.org/10.1080/15502783.2024.2441775
Journal volume & issue
Vol. 22, no. 1

Abstract

Read online

Position Statement: The International Society of Sports Nutrition (ISSN) presents this position based on a critical examination of the literature surrounding the effects of long-chain omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on exercise performance, recovery, and brain health. This position stand is intended to provide a scientific foundation for athletes, dietitians, trainers, and other practitioners regarding the effects of supplemental ω-3 PUFA in healthy and athletic populations. The following conclusions represent the official position of the ISSN: Athletes may be at a higher risk for ω-3 PUFA insufficiency.Diets rich in ω-3 PUFA, including supplements, are effective strategies for increasing ω-3 PUFA levels.ω-3 PUFA supplementation, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been shown to enhance endurance capacity and cardiovascular function during aerobic-type exercise.ω-3 PUFA supplementation may not confer a muscle hypertrophic benefit in young adults.ω-3 PUFA supplementation in combination with resistance training may improve strength in a dose- and duration-dependent manner.ω-3 PUFA supplementation may decrease subjective measures of muscle soreness following intense exercise.ω-3 PUFA supplementation can positively affect various immune cell responses in athletic populations.Prophylactic ω-3 PUFA supplementation may offer neuroprotective benefits in athletes exposed to repeated head impacts.ω-3 PUFA supplementation is associated with improved sleep quality.ω-3 PUFA are classified as prebiotics; however, studies on the gut microbiome and gut health in athletes are currently lacking.

Keywords