Nature Communications (Mar 2020)

Protein-polymer bioconjugates via a versatile oxygen tolerant photoinduced controlled radical polymerization approach

  • Alexis Theodorou,
  • Evelina Liarou,
  • David M. Haddleton,
  • Iren Georgia Stavrakaki,
  • Panagiotis Skordalidis,
  • Richard Whitfield,
  • Athina Anastasaki,
  • Kelly Velonia

DOI
https://doi.org/10.1038/s41467-020-15259-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Amphiphilic protein-polymer conjugates remain largely unexplored due to synthetic protocols being complex. Here the authors explore an oxygen tolerant, photoinduced reversible-deactivated radical polymerization approach, which readily affords quantitative yields within 2 h and thus avoids damage to the secondary structure of the proteins.