PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation

Seul Kim; Nam Hyun Kim; Ji Eun Park; Jee Won Hwang; Nayeon Myung; Ki-Tae Hwang; Young A Kim; Chang-Young Jang; Yong Kee Kim

doi:10.1038/s41467-020-14511-w

Nature Communications (Jan 2020)

PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation

Seul Kim,
Nam Hyun Kim,
Ji Eun Park,
Jee Won Hwang,
Nayeon Myung,
Ki-Tae Hwang,
Young A Kim,
Chang-Young Jang,
Yong Kee Kim

Affiliations

Seul Kim: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women’s University
Nam Hyun Kim: Department of Pharmacology, College of Medicine, Catholic Kwandong University
Ji Eun Park: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women’s University
Jee Won Hwang: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women’s University
Nayeon Myung: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women’s University
Ki-Tae Hwang: Department of Surgery, Seoul National University Boramae Medical Center
Young A Kim: Department of Pathology, Seoul National University Boramae Medical Center
Chang-Young Jang: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women’s University
Yong Kee Kim: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women’s University

DOI: https://doi.org/10.1038/s41467-020-14511-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The proteins of the chromosomal passenger complex help chromosomes condense before cell division, but how this complex arrives at chromosomes was not known. Here the authors show that PRMT6 methylates histone H3 to recruit the chromosomal passenger complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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