TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome

Abstract

Fertility treatment: Understanding ovarian hyperstimulation syndrome Insights into abnormal protein activity involved in ovarian hyperstimulation syndrome (OHSS) could inform future therapies. OHSS is a serious complication of fertility treatment where the body responds excessively to medication taken to help eggs grow, causing blood clots, pain, and even death. Scientists believe that high levels of the vascular endothelial growth factor (VEGF) protein trigger OHSS. Another protein involved in cell proliferation,transforming growth factor beta-1 (TGF-β1), may influence VEGF activity. Ying-Pu Sun and Jung-Chien Cheng at the First Affiliated Hospital of Zhengzhou University, Henan, China, and co-workers conducted experiments on human cell lines and OHSS mouse models. They found that TGF-β1 stimulates VEGF expression in human cells, and identified the associated signaling pathways. Both TGF-β1 and VEGF were increased in the ovaries of mice with OHSS, while blocking TGF-β1 halted OHSS progression.