The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma

Alexander Vdovin; Tomas Jelinek; David Zihala; Tereza Sevcikova; Michal Durech; Hana Sahinbegovic; Renata Snaurova; Dhwani Radhakrishnan; Marcello Turi; Zuzana Chyra; Tereza Popkova; Ondrej Venglar; Matous Hrdinka; Roman Hajek; Michal Simicek

doi:10.1038/s41467-022-34654-2

Nature Communications (Nov 2022)

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma

Alexander Vdovin,
Tomas Jelinek,
David Zihala,
Tereza Sevcikova,
Michal Durech,
Hana Sahinbegovic,
Renata Snaurova,
Dhwani Radhakrishnan,
Marcello Turi,
Zuzana Chyra,
Tereza Popkova,
Ondrej Venglar,
Matous Hrdinka,
Roman Hajek,
Michal Simicek

Affiliations

Alexander Vdovin: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Tomas Jelinek: Department of Hematooncology, Faculty of Medicine, University of Ostrava
David Zihala: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Tereza Sevcikova: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Michal Durech: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Hana Sahinbegovic: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Renata Snaurova: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Dhwani Radhakrishnan: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Marcello Turi: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Zuzana Chyra: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Tereza Popkova: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Ondrej Venglar: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Matous Hrdinka: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Roman Hajek: Department of Hematooncology, Faculty of Medicine, University of Ostrava
Michal Simicek: Department of Hematooncology, Faculty of Medicine, University of Ostrava

DOI: https://doi.org/10.1038/s41467-022-34654-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

Development of proteasome inhibitor resistance is a common problem in patients with multiple myeloma. Here, the authors show that deubiquitinase OTUD1 protects PRDX4 from degradation resulting in increased load of misfolded immunoglobulins sensitizing myeloma cells for proteasome inhibition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal