The emerging role of IL‐38 in diseases: A comprehensive review

Abstract

Abstract Introduction Interleukin‐38 (IL‐38) is a new type of anti‐inflammatory cytokine, which is mainly expressed in the immunity‐related organs and is involved in various diseases including cardiovascular and cerebrovascular diseases, lung diseases, viral infectious diseases and autoimmune diseases. Aim This review aims to detail the biological function, receptors and signaling of IL‐38, which highlights its therapeutic potential in related diseases. Conclusion This article provides a comprehensive review of the association between interleukin‐38 and related diseases, using interleukin‐38 as a keyword and searching the relevant literature through Pubmed and Web of science up to July 2023.

Keywords

• cardiovascular and cerebrovascular diseases
• interleukin‐38
• lung diseases
• signal path
• viral infectious diseasesautoimmune diseases