Al Ameen Journal of Medical Sciences (Jan 2020)
Study of association between serum uric acid and HbA1c levels in patients with type 2 diabetes mellitus
Abstract
Background: Type 2 diabetes mellitus is prevalent in a majority of population in India with approximately 30-35% and is fast gaining the status of a potential epidemic in India with more than 62 million diabetic individuals currently diagnosed with the disease. Plasma uric acid, an end product of purine metabolism, thought to be a metabolically inert end product without any physiological significance. An association between serum uric acid and type 2 diabetes mellitus is said to induce hyperinsulinemia and impaired glucose tolerance. Objectives: To identify the levels of serum uric acid in patients with Type 2 Diabetes mellitus and to find out the association between serum uric acid levels and HbA1c levels between patients and controls. Methods: A prospective observational study conducted over a period of 18 months from Jan 2018 to June 2019. Serum uric acid and serum glucose concentration were measured in 100 patients of which 50 controls and 50 patients groups. Results: Serum uric acid concentration was higher in diabetic group as compared with control group and was significant (p<0.001). Conclusion: There is no association between serum uric acid and HbA1c levels in patients with type 2 diabetes when compared with controls and was statistically significant with (p value 0.05).
