Sex disparities in the risk of urgent dialysis following acute aortic dissections in Japan

Yuta Nakano; Shintaro Mandai; Daiei Takahashi; Ken Ikenouchi; Yutaro Mori; Fumiaki Ando; Koichiro Susa; Takayasu Mori; Soichiro Iimori; Shotaro Naito; Eisei Sohara; Kiyohide Fushimi; Shinichi Uchida

iScience (Aug 2024)

Sex disparities in the risk of urgent dialysis following acute aortic dissections in Japan

Yuta Nakano,
Shintaro Mandai,
Daiei Takahashi,
Ken Ikenouchi,
Yutaro Mori,
Fumiaki Ando,
Koichiro Susa,
Takayasu Mori,
Soichiro Iimori,
Shotaro Naito,
Eisei Sohara,
Kiyohide Fushimi,
Shinichi Uchida

Affiliations

Yuta Nakano: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Shintaro Mandai: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan; Corresponding author
Daiei Takahashi: Department of Nephrology, Musashino Red Cross Hospital, 1-26-1, Kyonann-cho, Musashino-shi, Tokyo 180-8610, Japan
Ken Ikenouchi: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Yutaro Mori: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Fumiaki Ando: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Koichiro Susa: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Takayasu Mori: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Soichiro Iimori: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Shotaro Naito: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Eisei Sohara: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Kiyohide Fushimi: Department of Health Policy and Informatics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan
Shinichi Uchida: Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan; Corresponding author

Journal volume & issue: Vol. 27, no. 8
p. 110577

Abstract

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Summary: The global outcome of acute aortic dissection (AD) remains poor, with a high risk of the need for urgent dialysis. This study aimed to clarify the association between sex and the requirement for urgent dialysis within 30 days after admission among patients with AD. This study included 79,998 cases who were hospitalized due to AD in Japan from 2010 to 2020 using an administrative claims database. The association between the risk of urgent dialysis and sex was investigated using the Fine and Gray model. Patients were classified into two groups based on the Stanford classification: type A AD (TAAD) and type B AD (TBAD). The lower subdistribution hazard ratio (SHR) in women was observed in both groups: TAAD (SHR: 0.58, 95% confidence interval [CI]: 0.54–0.62); TBAD (SHR: 0.49, 95% CI: 0.41–0.58). Our study revealed that women had a lower risk of requiring urgent dialysis than men in TAAD and TBAD.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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