The Effect of Low Alcohol Consumption during Pregnancy on the Metabolic Processes of Women and Their Alcohol-Exposed Babies

Abstract

The aim of this study was to examine the effect of low or very low amounts of alcohol consumption on the LPO-AOD systems of pregnant women and their infants after birth, and the effect of that exposure on infant, growth, health, and development. Methods and Results: A sample of 201 pregnant women (mother-child dyads) was recruited for the study. Pregnant women were categorized into three groups according to the amount of alcohol they consume: 1) non-drinking, 2) very low drinking, and 3) low drinking. Small amounts of alcohol consumption caused dysfunction of the LPO-AOD system and the development of OS in women, and had negative effects on infants. The biomarkers of potentially harmful LPO, such as TBARs, were higher in very low and low drinking mothers. The activity of the AOD system was lower among mothers who drank alcohol. Alcohol consumption decreased levels of retinol, SOD activity, GSH, and GR activity. Higher rates of pathological conditions, delayed development, and slower growth were observed among infants who were prenatally exposed to alcohol. Conclusion: Identification and preventive interventions are needed for pregnant women who use alcohol in any amount.

Keywords

• lipid peroxidation
• antioxidant defense
• pregnant women
• infant
• alcohol