Effects of Tissue Coagulative Necrosis on Longitudinal Relaxation Time-Based Magnetic Resonance Thermometry

HONG Sheng-xiu; HU Hong-bing; YANG Zeng-tao; ZHANG Tian-feng; HUANG Lei; WANG Hua

doi:10.11938/cjmr20182624

Chinese Journal of Magnetic Resonance (Dec 2018)

Effects of Tissue Coagulative Necrosis on Longitudinal Relaxation Time-Based Magnetic Resonance Thermometry

HONG Sheng-xiu,
HU Hong-bing,
YANG Zeng-tao,
ZHANG Tian-feng,
HUANG Lei,
WANG Hua

Affiliations

HONG Sheng-xiu: State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering;Chongqing Key Laboratory of Biomedical Engineering;Chongqing Medical University, Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing 400016, China
HU Hong-bing: National Engineering Research Center of Ultrasound Medicine, Chongqing 401121, China
YANG Zeng-tao: State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering;Chongqing Key Laboratory of Biomedical Engineering;Chongqing Medical University, Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing 400016, China
ZHANG Tian-feng: State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering;Chongqing Key Laboratory of Biomedical Engineering;Chongqing Medical University, Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing 400016, China
HUANG Lei: State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering;Chongqing Key Laboratory of Biomedical Engineering;Chongqing Medical University, Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing 400016, China
WANG Hua: State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering;Chongqing Key Laboratory of Biomedical Engineering;Chongqing Medical University, Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing 400016, China

DOI: https://doi.org/10.11938/cjmr20182624
Journal volume & issue: Vol. 35, no. 4
pp. 440 – 446

Abstract

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Real-time monitoring of tissue temperature is required during high intensity focused ultrasound (HIFU) tumor treatment to ensure safety and effectiveness. Magnetic resonance imaging (MRI) can be used to measure tissue temperature non-invasively during HIFU treatment. This paper examined the effects of coagulation necrosis-induced tissue phase transition on magnetic resonance thermometry (MRT) during HIFU tumor treatment. With a two-state rapid exchange model, the relationship between tissue longitudinal relaxation time (T1) and temperature before and after HIFU radiation-induced coagulation necrosis/tissue phase transition were analyzed theoretically. Taking the effects of tissue phase transition into account, the experimental scheme and data processing procedures for MRT were optimized, and better temperature measurements were obtained. The work demonstrated the importance of considering the effects of tissue phase transition in real-time MRT during HIFU treatment.

Published in Chinese Journal of Magnetic Resonance

ISSN: 1000-4556 (Print)
Publisher: Science Press
Country of publisher: China
LCC subjects: Science: Physics: Electricity and magnetism
Website: http://121.43.60.238/bpxzz/EN/1000-4556/home.shtml

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