Advances in the use of dexmedetomidine for postoperative cognitive dysfunction

Abstract

Abstract Postoperative cognitive dysfunction, a common neurological complication in the perioperative period, seriously affects patient survival and prognosis. Its high incidence has made the study of postoperative cognitive dysfunction challenging. Whether the clinical application of dexmedetomidine, a potential neuroprotective drug, can reduce the incidence of postoperative cognitive dysfunction is controversial, although several potential mechanisms by which dexmedetomidine improves postoperative cognitive dysfunction have been identified; therefore, this remains an area in need of further exploration.

Keywords

• Dexmedetomidine
• Postoperative cognitive dysfunction
• Epigenetic mechanisms
• Cognitive neuroscience