RNA interference in glial cells for nerve injury treatment

Junquan Lin; Seung Bin Jo; Tae-Hyun Kim; Hae-Won Kim; Sing Yian Chew

doi:10.1177/2041731420939224

Journal of Tissue Engineering (Jul 2020)

RNA interference in glial cells for nerve injury treatment

Junquan Lin,
Seung Bin Jo,
Tae-Hyun Kim,
Hae-Won Kim,
Sing Yian Chew

Affiliations

Junquan Lin: School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore
Seung Bin Jo: Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea
Tae-Hyun Kim: Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea
Hae-Won Kim: UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of Korea
Sing Yian Chew: Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

DOI: https://doi.org/10.1177/2041731420939224
Journal volume & issue: Vol. 11

Abstract

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Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.

Published in Journal of Tissue Engineering

ISSN: 2041-7314 (Online)
Publisher: SAGE Publishing
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://journals.sagepub.com/home/tej

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