Dataset for the role of sustained attention in memory formation of transgenic mice for Alzheimer׳s disease
Natalia Mendes Schöwe,
Eduardo Moreira de Oliveira,
Hudson Sousa Buck,
Tania Araujo Viel
Affiliations
Natalia Mendes Schöwe
Graduate Course on Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
Eduardo Moreira de Oliveira
Graduate Course on Neurology, Department of Cognitive Neurology, School of Medicine, University of Sao Paulo, Brazil
Hudson Sousa Buck
Department of Physiological Sciences, Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil
Tania Araujo Viel
Graduate Course on Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil; School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, Brazil; Corresponding author.
Weekly submission of rats to active avoidance apparatus can be considered a neurostimulation strategy, once it can improve memory and can increase the density of receptors from different neurotransmitter systems in brain areas related to memory. These benefits were observed in rats chronically infused with amyloid-β peptide. In the present work it is presented that the same benefit for memory was observed in five months old transgenic mice for Alzheimer’s disease (TG-PDGFB-APPSw,Ind). However, at this age, no change in density of nicotinic receptors was observed. Keywords: Sustained attention, Memory, Alzheimer׳s disease, Nicotinic, Receptor, Hippocampus
