Research and Reports in Urology (May 2022)

The Correlation Between Platelet Count and Survival in Prostate Cancer

  • Mezei T,
  • Bőde I,
  • Tenke P,
  • Jósa V,
  • Merkel K,
  • Szilasi Z,
  • Tordai A,
  • Máthé D,
  • Baranyai Z

Journal volume & issue
Vol. Volume 14
pp. 193 – 202

Abstract

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Tünde Mezei,1 Imre Bőde,1 Péter Tenke,1 Valéria Jósa,2 Keresztély Merkel,3 Zsuzsanna Szilasi,4 Attila Tordai,5 Domokos Máthé,6 Zsolt Baranyai7 1Department of Urology, Jahn Ferenc South-Pest Hospital, Budapest, Hungary; 2Department of Otorhinolaryngology and Head and Neck Surgery, Jahn Ferenc South-Pest Hospital, Budapest, Hungary; 3Department of Surgery, Szent Imre Hospital, Budapest, Hungary; 4Department of Otorhinolaryngology and Head and Neck Surgery, HDF Medical Centre, Budapest, Hungary; 5Institute of Pathophysiology, Semmelweis University, Budapest, Hungary; 6Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary; 7Semmelweis University, Department of Transplantation and Surgery, Budapest, HungaryCorrespondence: Tünde Mezei, Jahn Ferenc South-Pest Hospital, Department of Urology, Budapest, Hungary, Köves str 1, Budapest, 1204, Hungary, Tel +3620/2013038, Email [email protected]: A number of studies have confirmed that elevated platelet count accompanying various solid tumours is associated with worse survival. However, only meagre data are available on the relationship between thrombocytosis and survival in prostate cancer.Methods: We conducted a retrospective analysis on clinical-pathological data accumulated from 316 patients during on average 51 months of follow-up after laparoscopic prostatectomy performed for prostate cancer. We analyzed the relationship between platelet count, risk factors, prostate-specific antigen (PSA) and cancer stage with use the Tumor, Node, Metastase system (TNM), as well as surgical margin, and prognosis.Results: Thrombocytosis occurred in only one out of the 316 patients. The multivariate Cox proportional hazard model showed that preoperative PSA, risk group, preoperative haemoglobin level, and surgical margin status were significant, independent predictors of biochemical progression-free survival. By contrast, age at diagnosis and thrombocytosis had no such predictive value.Conclusion: We could not demonstrate an association between elevated platelet count and worse survival in our study population of patients with prostate cancer.Keywords: prostate cancer, thrombocytosis, prognosis, pathomechanism, solid tumor

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