Activation mechanism of human soluble guanylate cyclase by stimulators and activators

Rui Liu; Yunlu Kang; Lei Chen

doi:10.1038/s41467-021-25617-0

Nature Communications (Sep 2021)

Activation mechanism of human soluble guanylate cyclase by stimulators and activators

Rui Liu,
Yunlu Kang,
Lei Chen

Affiliations

Rui Liu: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
Yunlu Kang: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
Lei Chen: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University

DOI: https://doi.org/10.1038/s41467-021-25617-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Soluble guanylate cyclase (sGC) is a validated drug target for cardiovascular diseases. Here, the authors report structures of human sGC in complex with NO and sGC stimulators or activator, providing insight into the mechanism of sGC activation by pharmacological compounds.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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