The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis

Zhi Lin; Jiao Liu; Fei Long; Rui Kang; Guido Kroemer; Daolin Tang; Minghua Yang

doi:10.1038/s41467-022-35707-2

Nature Communications (Dec 2022)

The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis

Zhi Lin,
Jiao Liu,
Fei Long,
Rui Kang,
Guido Kroemer,
Daolin Tang,
Minghua Yang

Affiliations

Zhi Lin: Department of Pediatrics, The Third Xiangya Hospital, Central South University
Jiao Liu: DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University
Fei Long: Department of Gastrointestinal Surgery, The Third Xiangya Hospital, Central South University
Rui Kang: Department of Surgery, UT Southwestern Medical Center
Guido Kroemer: Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France
Daolin Tang: Department of Surgery, UT Southwestern Medical Center
Minghua Yang: Department of Pediatrics, The Third Xiangya Hospital, Central South University

DOI: https://doi.org/10.1038/s41467-022-35707-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Ferroptosis is cell death caused by lipid peroxidation and plasma membrane rupture. Here, the authors report an additional role for the lipid flippase SLC47A1 as a regulator of lipid remodeling and survival during ferroptosis, thereby providing a metabolic target for overcoming drug resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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