Chromatin accessibility associates with protein-RNA correlation in human cancer

Akshay Sanghi; Joshua J. Gruber; Ahmed Metwally; Lihua Jiang; Warren Reynolds; John Sunwoo; Lisa Orloff; Howard Y. Chang; Maya Kasowski; Michael P. Snyder

doi:10.1038/s41467-021-25872-1

Nature Communications (Sep 2021)

Chromatin accessibility associates with protein-RNA correlation in human cancer

Akshay Sanghi,
Joshua J. Gruber,
Ahmed Metwally,
Lihua Jiang,
Warren Reynolds,
John Sunwoo,
Lisa Orloff,
Howard Y. Chang,
Maya Kasowski,
Michael P. Snyder

Affiliations

Akshay Sanghi: Department of Genetics, Stanford University
Joshua J. Gruber: Department of Genetics, Stanford University
Ahmed Metwally: Department of Genetics, Stanford University
Lihua Jiang: Department of Genetics, Stanford University
Warren Reynolds: Center for Personal Dynamic Regulomes and HHMI, Stanford University
John Sunwoo: Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University School of Medicine
Lisa Orloff: Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University School of Medicine
Howard Y. Chang: Department of Genetics, Stanford University
Maya Kasowski: Department of Genetics, Stanford University
Michael P. Snyder: Department of Genetics, Stanford University

DOI: https://doi.org/10.1038/s41467-021-25872-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Studies show the cancer transcriptome correlates poorly with the cancer proteome, questioning the role of chromatin regulation. Here the authors demonstrate proximal-gene-body chromatin elements and transcription predict abundances of differentially expressed proteins in thyroid and breast cancers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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