Depolymerization of P4HB and PBS Waste and Synthesis of the Anticancer Drug Busulfan from Plastic Waste

Abstract

Sustainable synthesis of pharmaceuticals is one of the main challenges for the pharmaceutical industry. Production of these compounds from plastic waste can provide an innovative and ecological approach to their sustainable synthesis. In this context, plastic waste can be regarded as a potential cheap resource for the production of compounds of interest to the pharmaceutical industry. In this work, the first methodologies for the reductive depolymerization of poly(4-hydroxybutyrate) (P4HB) and polybutylene succinate (PBS) plastic waste are reported using the catalyst systems MoO2Cl2(H2O)2/silane, MoO2Cl2(H2O)2/borane and KOH/PhSiH3 with moderate to excellent yields. We also developed the first synthetic strategy for the synthesis of a drug, the anticancer busulfan, from P4HB and PBS plastic waste with moderate overall yields.

Keywords

• plastic waste
• poly(4-hydroxybutyrate)
• polybutylene succinate
• reductive depolymerization
• busulfan