<i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity

Giuseppina Rosaria Umano; Grazia Cirillo; Giulia Rondinelli; Gianmaria Sanchez; Pierluigi Marzuillo; Stefano Guarino; Anna Di Sessa; Alfonso Papparella; Emanuele Miraglia del Giudice

doi:10.3390/genes14081618

Genes (Aug 2023)

<i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity

Giuseppina Rosaria Umano,
Grazia Cirillo,
Giulia Rondinelli,
Gianmaria Sanchez,
Pierluigi Marzuillo,
Stefano Guarino,
Anna Di Sessa,
Alfonso Papparella,
Emanuele Miraglia del Giudice

Affiliations

Giuseppina Rosaria Umano: Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Grazia Cirillo: Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Giulia Rondinelli: Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Gianmaria Sanchez: Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Pierluigi Marzuillo: Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Stefano Guarino: Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Anna Di Sessa: Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Alfonso Papparella: Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Emanuele Miraglia del Giudice: Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

DOI: https://doi.org/10.3390/genes14081618
Journal volume & issue: Vol. 14, no. 8
p. 1618

Abstract

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Childhood obesity and its related comorbidities have become major health issues over the last century. Among these comorbidities, cardiovascular diseases, especially hypertension, are the most significant. Recently, a polymorphism affecting the activity of lanosterol synthase has been associated with an increased risk of hypertension in adolescents. In this study, we aimed to investigate the effect of LSS rs2254524 polymorphism on blood pressure in children and adolescents with obesity. We enrolled 828 obese children aged 6–17 years. Subjects carrying the A allele showed higher rates of systolic and diastolic stage I hypertension and stage II hypertension. Carriers of the A allele showed a 2.4-fold (95% C.I. 1.5–4.7, p = 0.01) higher risk for stage II hypertension and a 1.9-fold higher risk for stage I hypertension (95% C.I. 1.4–2.6, p LSS rs2254524 worsens the cardiovascular health of children and adolescents with obesity, increasing their blood pressure.

Published in Genes

ISSN: 2073-4425 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://www.mdpi.com/journal/genes/

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