A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients

Zhe Zhang; Wenjing Yang; Zhengshan Chen; Haoang Chi; Shipo Wu; Wanru Zheng; Ruochun Jin; Busen Wang; Yudong Wang; Nan Huo; Jinlong Zhang; Xiaohong Song; Liyang Xu; Jun Zhang; Lihua Hou; Wei Chen

The Innovation (May 2024)

A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients

Zhe Zhang,
Wenjing Yang,
Zhengshan Chen,
Haoang Chi,
Shipo Wu,
Wanru Zheng,
Ruochun Jin,
Busen Wang,
Yudong Wang,
Nan Huo,
Jinlong Zhang,
Xiaohong Song,
Liyang Xu,
Jun Zhang,
Lihua Hou,
Wei Chen

Affiliations

Zhe Zhang: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Wenjing Yang: Department of Intelligent Data Science, College of Computer Science and Technology, National University of Defense Technology, Changsha 410073, China
Zhengshan Chen: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Haoang Chi: Intelligent Game and Decision Lab, Academy of Military Science, Beijing 100091, China; Department of Intelligent Data Science, College of Computer Science and Technology, National University of Defense Technology, Changsha 410073, China
Shipo Wu: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Wanru Zheng: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Ruochun Jin: Department of Intelligent Data Science, College of Computer Science and Technology, National University of Defense Technology, Changsha 410073, China
Busen Wang: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Yudong Wang: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Nan Huo: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Jinlong Zhang: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Xiaohong Song: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Liyang Xu: Department of Intelligent Data Science, College of Computer Science and Technology, National University of Defense Technology, Changsha 410073, China
Jun Zhang: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
Lihua Hou: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China; Corresponding author
Wei Chen: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China; Corresponding author

Journal volume & issue: Vol. 5, no. 3
p. 100603

Abstract

Read online

The vaccine-induced innate immune response is essential for the generation of an antibody response. To date, how Ad5-vectored vaccines are influenced by preexisting anti-Ad5 antibodies during activation of the early immune response remains unclear. Here, we investigated the specific alterations in GP1,2-specific IgG-related elements of the early immune response at the genetic, molecular, and cellular levels on days 0, 1, 3, and 7 after Ad5-EBOV vaccination. In a causal multiomics analysis, distinct early immune responses associated with GP1,2-specific IgG were observed in Ad5-EBOV recipients with a low level of preexisting anti-Ad5 antibodies. This study revealed the correlates of the Ad5-EBOV-induced IgG response and provided mechanistic evidence for overcoming preexisting Ad5 immunity during the administration of Ad5-vectored vaccines.

Published in The Innovation

ISSN: 2666-6758 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Science (General)
Website: https://www.cell.com/the-innovation

About the journal