Nature Communications (Jun 2019)

Structural basis for the inhibition of translation through eIF2α phosphorylation

  • Yuliya Gordiyenko,
  • José Luis Llácer,
  • V. Ramakrishnan

DOI
https://doi.org/10.1038/s41467-019-10606-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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During stress, protein synthesis is inhibited through phosphorylation of the initiation factor eIF2 on its alpha subunit and its interaction with eIF2B. Here the authors describe a structure of the yeast eIF2B in complex with its substrate - the GDP-bound phosphorylated eIF2, providing insights into how phosphorylation results in a tighter interaction with eIF2B.