The Metabolism and Immune Environment in Diffuse Large B-Cell Lymphoma
Jianbo Wu,
Fuqing Meng,
Danyang Ran,
Yalong Song,
Yunkun Dang,
Fan Lai,
Longyan Yang,
Mi Deng,
Yuqin Song,
Jun Zhu
Affiliations
Jianbo Wu
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China
Fuqing Meng
School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China
Danyang Ran
School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China
Yalong Song
Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650500, China
Yunkun Dang
Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650500, China
Fan Lai
Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650500, China
Longyan Yang
Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China
Mi Deng
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China
Yuqin Song
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China
Jun Zhu
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China
Cells utilize different metabolic processes to maintain their growth and differentiation. Tumor cells have made some metabolic changes to protect themselves from malnutrition. These metabolic alterations affect the tumor microenvironment and macroenvironment. Developing drugs targeting these metabolic alterations could be a good direction. In this review, we briefly introduce metabolic changes/regulations of the tumor macroenvironment and microenvironment and summarize potential drugs targeting the metabolism in diffuse large B-cell lymphoma.
