Prognostic Role of Functional SYNTAX Score Based on Quantitative Flow Ratio
Dimitrios Terentes-Printzios,
Konstantia-Paraskevi Gkini,
Dimitrios Oikonomou,
Vasiliki Gardikioti,
Konstantinos Aznaouridis,
Ioanna Dima,
Konstantinos Tsioufis,
Charalambos Vlachopoulos
Affiliations
Dimitrios Terentes-Printzios
First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias St., 11527 Athens, Greece
Konstantia-Paraskevi Gkini
First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias St., 11527 Athens, Greece
Dimitrios Oikonomou
First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias St., 11527 Athens, Greece
Vasiliki Gardikioti
First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias St., 11527 Athens, Greece
Konstantinos Aznaouridis
First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias St., 11527 Athens, Greece
Ioanna Dima
First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias St., 11527 Athens, Greece
Konstantinos Tsioufis
First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias St., 11527 Athens, Greece
Charalambos Vlachopoulos
First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias St., 11527 Athens, Greece
Background/Objectives: The quantitative flow ratio (QFR)-based functional Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score (FSSQFR) combines coronary arteries’ anatomy and physiology. Methods: We performed an offline FSSQFR calculation in all-comers undergoing coronary angiography in a single center. Based on the tertiles of SYNTAX Score (SS), patients were divided into low-, intermediate-, and high-risk groups with the following cut-offs: SS/FSSQFR 21. The primary endpoint was the predictive value of the FSSQFR of the composite endpoint of all-cause death, myocardial infarction, ischemia-driven revascularization, hospitalization for heart failure, and life-threatening arrhythmias after the follow-up period. Results: This study included 410 patients. SS and FSSQFR were measured for all patients. After calculating FSSQFR, the risk stratification changed in 11% of the study population; more specifically, 26.8, 32.7, and 40.5% of patients were classified as high-, intermediate-, and low-risk, respectively. After a median 30.2 (25.7–33.7) months follow-up period, we recorded 85 events of the primary outcome. The high-risk FSSQFR group compared to the low-risk group had a significantly higher rate of the primary composite outcome (HR: 1.95, 95% CI 1.33–3.34, p = 0.016). Conclusions: In our study, patients classified as the high-risk FSSQFR group had a significantly higher rate of cardiovascular adverse events.
