Revista da Sociedade Brasileira de Medicina Tropical ()

Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C

  • Aline Aki Tanikawa,
  • Rejane Maria Tommasini Grotto,
  • Giovanni Faria Silva,
  • Adriana Camargo Ferrasi,
  • Valéria Cristina Rodrigues Sarnighausen,
  • Maria Inês de Moura Campos Pardini

DOI
https://doi.org/10.1590/0037-8682-0302-2016
Journal volume & issue
Vol. 50, no. 1
pp. 113 – 116

Abstract

Read online

Abstract: INTRODUCTION: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. METHODS: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. RESULTS: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. CONCLUSIONS: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis.

Keywords