Frontiers in Immunology (Jun 2019)

An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease

  • Liang Shao,
  • Shan Pan,
  • Qiu-ping Zhang,
  • Muhammad Jamal,
  • Lu-hua Chen,
  • Qian Yin,
  • Ying-jie Wu,
  • Jie Xiong,
  • Rui-jing Xiao,
  • Yok-lam Kwong,
  • Fu-ling Zhou,
  • Albert K. W. Lie

DOI
https://doi.org/10.3389/fimmu.2019.01233
Journal volume & issue
Vol. 10

Abstract

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Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.

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