Gut Bacterial Characteristics of Patients With Type 2 Diabetes Mellitus and the Application Potential

Yanyan Que; Man Cao; Jianquan He; Jianquan He; Qiang Zhang; Qiang Zhang; Qiongyun Chen; Qiongyun Chen; Changsheng Yan; Changsheng Yan; Aiqiang Lin; Luxi Yang; Zezhen Wu; Zezhen Wu; Dan Zhu; Fengwu Chen; Zhangran Chen; Zhangran Chen; Chuanxing Xiao; Chuanxing Xiao; Kaijian Hou; Bangzhou Zhang; Bangzhou Zhang

doi:10.3389/fimmu.2021.722206

Frontiers in Immunology (Aug 2021)

Gut Bacterial Characteristics of Patients With Type 2 Diabetes Mellitus and the Application Potential

Yanyan Que,
Man Cao,
Jianquan He,
Jianquan He,
Qiang Zhang,
Qiang Zhang,
Qiongyun Chen,
Qiongyun Chen,
Changsheng Yan,
Changsheng Yan,
Aiqiang Lin,
Luxi Yang,
Zezhen Wu,
Zezhen Wu,
Dan Zhu,
Fengwu Chen,
Zhangran Chen,
Zhangran Chen,
Chuanxing Xiao,
Chuanxing Xiao,
Kaijian Hou,
Bangzhou Zhang,
Bangzhou Zhang

Affiliations

Yanyan Que: Department of Endocrinology, Zhongshan Hospital Xiamen University, Xiamen, China
Man Cao: Department of Mathematics and Numerical Simulation and High-Performance Computing Laboratory, School of Sciences, Nanchang University, Nanchang, China
Jianquan He: Department of Rehabilitation, Zhongshan Hospital Xiamen University, Xiamen, China
Jianquan He: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China
Qiang Zhang: Department of Gastroenterology, Zhongshan Hospital Xiamen University, Xiamen, China
Qiang Zhang: School of Medicine, Xiamen University, Xiamen, China
Qiongyun Chen: Department of Gastroenterology, Zhongshan Hospital Xiamen University, Xiamen, China
Qiongyun Chen: School of Medicine, Xiamen University, Xiamen, China
Changsheng Yan: Department of Gastroenterology, Zhongshan Hospital Xiamen University, Xiamen, China
Changsheng Yan: School of Medicine, Xiamen University, Xiamen, China
Aiqiang Lin: Department of Research and Development, Xiamen Treatgut Biotechnology Co., Ltd., Xiamen, China
Luxi Yang: School of Medicine, Xiamen University, Xiamen, China
Zezhen Wu: Department of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, China
Zezhen Wu: Graduate School, Medical College of Shantou University, Shantou, China
Dan Zhu: Department of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, China
Fengwu Chen: Department of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, China
Zhangran Chen: Department of Gastroenterology, Zhongshan Hospital Xiamen University, Xiamen, China
Zhangran Chen: School of Medicine, Xiamen University, Xiamen, China
Chuanxing Xiao: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China
Chuanxing Xiao: School of Medicine, Xiamen University, Xiamen, China
Kaijian Hou: Department of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, China
Bangzhou Zhang: Department of Gastroenterology, Zhongshan Hospital Xiamen University, Xiamen, China
Bangzhou Zhang: School of Medicine, Xiamen University, Xiamen, China

DOI: https://doi.org/10.3389/fimmu.2021.722206
Journal volume & issue: Vol. 12

Abstract

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Type 2 diabetes mellitus (T2DM) is a complex disorder comprehensively influenced by genetic and environmental risk, and research increasingly has indicated the role of microbial dysbiosis in T2DM pathogenesis. However, studies comparing the microbiome characteristics between T2DM and healthy controls have reported inconsistent results. To further identify and describe the characteristics of the intestinal flora of T2DM patients, we performed a systematic review and meta-analysis of stool microbial profiles to discern and describe microbial dysbiosis in T2DM and to explore heterogeneity among 7 studies (600 T2DM cases, 543 controls, 1143 samples in total). Using a random effects model and a fixed effects model, we observed significant differences in beta diversity, but not alpha diversity, between individuals with T2DM and controls. We identified various operational taxonomic unit (OTUs) and bacterial genera with significant odds ratios for T2DM. The T2DM signatures derived from a single study by stepwise feature selection could be applied in other studies. By training on multiple studies, we improved the detection accuracy and disease specificity for T2DM. We also discuss the relationship between T2DM-enriched or T2DM-depleted genera and probiotics and provide new ideas for diabetes prevention and improvement.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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