Frontiers in Neuroinformatics (Aug 2024)
Investigating cortical complexity and connectivity in rats with schizophrenia
- Zongya Zhao,
- Zongya Zhao,
- Zongya Zhao,
- Yifan Feng,
- Yifan Feng,
- Menghan Wang,
- Menghan Wang,
- Jiarong Wei,
- Jiarong Wei,
- Tao Tan,
- Tao Tan,
- Ruijiao Li,
- Ruijiao Li,
- Heshun Hu,
- Heshun Hu,
- Mengke Wang,
- Mengke Wang,
- Peiqi Chen,
- Peiqi Chen,
- Xudong Gao,
- Xudong Gao,
- Yinping Wei,
- Yinping Wei,
- Chang Wang,
- Chang Wang,
- Chang Wang,
- Zhixian Gao,
- Zhixian Gao,
- Zhixian Gao,
- Wenshuai Jiang,
- Wenshuai Jiang,
- Wenshuai Jiang,
- Xuezhi Zhou,
- Xuezhi Zhou,
- Xuezhi Zhou,
- Mingcai Li,
- Mingcai Li,
- Mingcai Li,
- Chong Wang,
- Chong Wang,
- Chong Wang,
- Ting Pang,
- Ting Pang,
- Ting Pang,
- Yi Yu,
- Yi Yu,
- Yi Yu
Affiliations
- Zongya Zhao
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Zongya Zhao
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Zongya Zhao
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Yifan Feng
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Yifan Feng
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Menghan Wang
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Menghan Wang
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Jiarong Wei
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Jiarong Wei
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Tao Tan
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Tao Tan
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Ruijiao Li
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Ruijiao Li
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Heshun Hu
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Heshun Hu
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Mengke Wang
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Mengke Wang
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Peiqi Chen
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Peiqi Chen
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Xudong Gao
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Xudong Gao
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Yinping Wei
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Yinping Wei
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Chang Wang
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Chang Wang
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Chang Wang
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Zhixian Gao
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Zhixian Gao
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Zhixian Gao
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Wenshuai Jiang
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Wenshuai Jiang
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Wenshuai Jiang
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Xuezhi Zhou
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Xuezhi Zhou
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Xuezhi Zhou
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Mingcai Li
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Mingcai Li
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Mingcai Li
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Chong Wang
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Chong Wang
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Chong Wang
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Ting Pang
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Ting Pang
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Ting Pang
- Center of Image and Signal Processing, Faculty of Computer Science and Information Technology, Universiti Malaya, Kuala Lumpur, Malaysia
- Yi Yu
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Yi Yu
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Yi Yu
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- DOI
- https://doi.org/10.3389/fninf.2024.1392271
- Journal volume & issue
-
Vol. 18
Abstract
BackgroundThe above studies indicate that the SCZ animal model has abnormal gamma oscillations and abnormal functional coupling ability of brain regions at the cortical level. However, few researchers have focused on the correlation between brain complexity and connectivity at the cortical level. In order to provide a more accurate representation of brain activity, we studied the complexity of electrocorticogram (ECoG) signals and the information interaction between brain regions in schizophrenic rats, and explored the correlation between brain complexity and connectivity.MethodsWe collected ECoG signal from SCZ rats. The frequency domain and time domain functional connectivity of SCZ rats were evaluated by magnitude square coherence and mutual information (MI). Permutation entropy (PE) and permutation Lempel-Ziv complexity (PLZC) were used to analyze the complexity of ECoG, and the relationship between them was evaluated. In addition, in order to further understand the causal structure of directional information flow among brain regions, we used phase transfer entropy (PTE) to analyze the effective connectivity of the brain.ResultsFirstly, in the high gamma band, the complexity of brain regions in SCZ rats is higher than that in normal rats, and the neuronal activity is irregularity. Secondly, the information integration ability of SCZ rats decreased and the communication of brain network information was hindered at the cortical level. Finally, compared with normal rats, the causal relationship between brain regions of SCZ rats was closer, but the information interaction center was not clear.ConclusionThe above findings suggest that at the cortical level, complexity and connectivity are valid biomarkers for identifying SCZ. This bridges the gap between peak potentials and EEG. This may help to understand the pathophysiological mechanisms at the cortical level in schizophrenics.
Keywords
