Association of insertion deletion polymorphism of the ACE gene with factors of circulating rennin-angiotensin-aldosterone system and endothelial function of skin microvassals in preeclampsia

Abstract

The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with plasma ACE, renin activity and endothelial function of skin microvassals were studied. Preeclamptic patients with the DD genotype of ACE I/D gene polymorphism have lowest plasma renin activity level and endothelium-dependent vasodilatation, D allele carriers have highest plasma ACE activity.

Keywords

• гестоз
• эндотелиальная дисфункция
• ангиотензинпревращающий фермент
• ренин
• полиморфизм генов