Bio-thermal non-equilibrium dynamics and thermal damage in biological tissues induced by multiple time pulse-laser irradiations

Abstract

Background: Laser therapy offers precise medical treatment by directing focused light beams to specific areas without harming surrounding tissue. This precision is particularly valuable in tissue treatment, including cancer therapy, where minimizing collateral damage is critical. The current study focuses on bio-thermal dynamics and thermal damage in biological tissues induced by multiple pulse-laser irradiations. Model: The Local Thermal Non-Equilibrium (LTNE) bio-heat Transfer model with porosity and dual lag effects is developed to investigate the thermal behavior in tissues. The model contains partial differential equations that is solved through numerical method. Results: Obtained results show temperature variations and thermal damage in tissues, influenced by parameters such as laser intensity, incident duration, and tissue porosity. Higher intensity of laser and extended laser durations increase the temperature distribution and thermal damage. Porosity inversely affects temperature distribution, with large values of porosity leading to decreased distribution. Novelty: This study introduces the application of multi-time lasers induced on tissue for the therapies, a novel approach that has not been previously explored in the literature.

Keywords

• Local thermal non-equilibrium bioheat
• Multiple pulse-lasers
• Temperature profile
• Thermal damage