Characteristics of cardiac contractile function changes in combined model of experimental arterial hypertension and acute coronary insufficiency after treatment with calcium channel blockers

Abstract

The functional state of cardiovascular system was studied in a rabbit model of acute coronary insufficiency and arterial hypertension treated with Calcium channel blocker verapamil. It was established that the potential working capacity of cardiac left ventricle decreases more significantly in case of 6-week experimental model of arterial hypertension in comparison with acute coronary insufficiency, which affect more considerably the working capacity of the right ventricle. We also assume that the favorable effect of verapamil on the parameters of heart contractile function in case of arterial hypertension with consequent development of acute coronary insufficiency is linked to the preservation of right ventricle's functional reserve.

Keywords

• артериальная гипертензия
• острая коронарная недостаточность
• сократительная функция
• сердца
• верапамил