17β-Estradiol promotes the synthesis and the secretion of annexin I in the CCRF-CEM human cell line

Margarida Castro-Caldas; Carlos B. Duarte; Arsélio P. Carvalho; M. Celeste Lopes

doi:10.1080/09629350120093713

Mediators of Inflammation (Jan 2001)

17β-Estradiol promotes the synthesis and the secretion of annexin I in the CCRF-CEM human cell line

Margarida Castro-Caldas,
Carlos B. Duarte,
Arsélio P. Carvalho,
M. Celeste Lopes

Affiliations

Margarida Castro-Caldas: Center for Neuroscience of Coimbra, Department of Zoology, University of Coimbra, Coimbra 3004–517, Portugal
Carlos B. Duarte: Center for Neuroscience of Coimbra, Department of Zoology, University of Coimbra, Coimbra 3004–517, Portugal
Arsélio P. Carvalho: Center for Neuroscience of Coimbra, Department of Zoology, University of Coimbra, Coimbra 3004–517, Portugal
M. Celeste Lopes: Center for Neuroscience of Coimbra, Department of Zoology, University of Coimbra, Coimbra 3004–517, Portugal

DOI: https://doi.org/10.1080/09629350120093713
Journal volume & issue: Vol. 10, no. 5
pp. 245 – 251

Abstract

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Aims: Annexin I (ANXA1), a 37 kDa member of the annexin family of Ca2+-binding and phospholipidbinding proteins, is particularly abundant in various populations of peripheral blood leukocytes. Since this protein modulates the anti-inflammatory actions of the steroid hormones, the purpose of this study was to investigate the effects of the female sex steroid hormone, 17β-estradiol (E2β), on the synthesis and secretion of ANXA1 in the human CCRF-CEM acute lymphoblastic leukemia cell line.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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