Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants

Hristo L. Svilenov; Romina Bester; Julia Sacherl; Ramona Absmeier; Carsten Peters; Ulrike Protzer; Carsten Brockmeyer; Johannes Buchner

doi:10.1038/s42003-022-04193-z

Communications Biology (Nov 2022)

Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants

Hristo L. Svilenov,
Romina Bester,
Julia Sacherl,
Ramona Absmeier,
Carsten Peters,
Ulrike Protzer,
Carsten Brockmeyer,
Johannes Buchner

Affiliations

Hristo L. Svilenov: Center for Protein Assemblies and Department Chemie, Technical University of Munich
Romina Bester: Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
Julia Sacherl: Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
Ramona Absmeier: Center for Protein Assemblies and Department Chemie, Technical University of Munich
Carsten Peters: Center for Protein Assemblies and Department Chemie, Technical University of Munich
Ulrike Protzer: Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
Carsten Brockmeyer: Formycon AG, Martinsried/Planegg
Johannes Buchner: Center for Protein Assemblies and Department Chemie, Technical University of Munich

DOI: https://doi.org/10.1038/s42003-022-04193-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 7

Abstract

Read online

Fusion of ACE2 to IgM-Fc results in hexameric ACE2-IgM-Fc proteins with potent virus neutralization efficiency of patient-isolated SARS-CoV and SARS-CoV-2 variants.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal