6 Pre-clinical pharmacodynamic biomarker assays of immune modulation can translate to inform exploratory endpoints of target engagement in first-in-human clinical trial stages of drug discovery

• Russell Garland,
• Christopher Kirkham,
• Michelle Yap,
• Louise Brackenbury,
• Tommaso Iannitti,
• Robert Nunan,
• S Jenkinson

Affiliations

Russell Garland

1Charles River Laboratories, Portishead, UK

Christopher Kirkham

2CRL, Bristol UK, UK

Michelle Yap

2CRL, Bristol UK, UK

Louise Brackenbury

2CRL, Bristol UK, UK

Tommaso Iannitti

2CRL, Bristol UK, UK

Robert Nunan

2CRL, Bristol UK, UK

S Jenkinson

2CRL, Bristol UK, UK