Bisphosphonate - Related Osteonecrosis of the Jaw – Five Years Experience

Abstract

Background. Osteonecrosis related to bisphosphonate therapy is a challenging disease with complicated treatment. It is well known among the maxillofacial surgeons all around the world since 2003. Despite of it, the incidence is still rising, because of the lack of prevention before using bisphosphonates. Disturbing the bone metabolism leads by even a small trauma to enormous defects, that is despite of intensive therapy irreversible. Treatment of this disease is commonly joint with losing the bone tissue and badly affects the quality of life. Often is necessary the combined therapy, surgery, antibiotics and antimycotics. The discontinuation of bisphosphonate treatment during the osteonecrosis therapy is also recommended if it is possible.

Keywords

• bisphosphonate
• osteonecrosis
• jaw
• therapy