Pathophisiology of the gastrointestinal tract in general unintentional overheating of the body (scientific and literature review)

Abstract

In thermal injury, the gastrointestinal tract is the target organ. General overheating of the body causes intestinal barrier breakdown, translocation of bacteria and enterotoxins, oxidative shock, etc. These complications significantly aggravate the course of the pathological condition, increase the duration of treatment and mortality. However, this issue is practically not covered in domestic literary sources. Based on the data from foreign special literature and our own clinical experience, we managed to systematize the main pathological points of pathogenesis, course and therapeutic approach in gastrointestinal lesions due to general unintentional overhea­ting of the body.

Keywords

• heat injury
• heat stress
• heat stroke
• intestinal barrier
• oxidant shock
• endotoxicosis