Nature Communications (Dec 2022)
Neural precursor cells tune striatal connectivity through the release of IGFBPL1
- Erica Butti,
- Stefano Cattaneo,
- Marco Bacigaluppi,
- Marco Cambiaghi,
- Giulia Maria Scotti,
- Elena Brambilla,
- Francesca Ruffini,
- Giacomo Sferruzza,
- Maddalena Ripamonti,
- Fabio Simeoni,
- Laura Cacciaguerra,
- Aurora Zanghì,
- Angelo Quattrini,
- Riccardo Fesce,
- Paola Panina-Bordignon,
- Francesca Giannese,
- Davide Cittaro,
- Tanja Kuhlmann,
- Patrizia D’Adamo,
- Maria Assunta Rocca,
- Stefano Taverna,
- Gianvito Martino
Affiliations
- Erica Butti
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- Stefano Cattaneo
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- Marco Bacigaluppi
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- Marco Cambiaghi
- Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona
- Giulia Maria Scotti
- Omics Sciences Center, IRCCS San Raffaele Hospital
- Elena Brambilla
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- Francesca Ruffini
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- Giacomo Sferruzza
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- Maddalena Ripamonti
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- Fabio Simeoni
- Omics Sciences Center, IRCCS San Raffaele Hospital
- Laura Cacciaguerra
- Neuroimaging Research Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Hospital
- Aurora Zanghì
- Neuroimaging Research Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Hospital
- Angelo Quattrini
- Neuropathology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Hospital
- Riccardo Fesce
- Department of Biomedical Sciences, Humanitas University, Pieve Emanuele
- Paola Panina-Bordignon
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- Francesca Giannese
- Omics Sciences Center, IRCCS San Raffaele Hospital
- Davide Cittaro
- Omics Sciences Center, IRCCS San Raffaele Hospital
- Tanja Kuhlmann
- Institute of Neuropathology, University Hospital Muster
- Patrizia D’Adamo
- Molecular genetics of Intellectual Disability, Division of Neuroscience, IRCCS San Raffaele Hospital
- Maria Assunta Rocca
- Vita-Salute San Raffaele University
- Stefano Taverna
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- Gianvito Martino
- Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
- DOI
- https://doi.org/10.1038/s41467-022-35341-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
The physiological role of endogenous neural protenitor cells of the subventricular zone in adult stage is not fully understood. Here the authors show that in mice, these cells tune neuronal activity of the striatum via insulin-like growth factor binding protein-like 1 and cognitive functions.
