Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis

Sunita Khatkar; Santosh Kumar Dubey; Priyanka Saraf; Jitender Kumar Bhardwaj; Satish Kumar; V. Kumar; Gaje Singh; Shayoraj

Results in Chemistry (Jan 2022)

Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis

Sunita Khatkar,
Santosh Kumar Dubey,
Priyanka Saraf,
Jitender Kumar Bhardwaj,
Satish Kumar,
V. Kumar,
Gaje Singh,
Shayoraj

Affiliations

Sunita Khatkar: Department of Chemistry, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, India
Santosh Kumar Dubey: Department of Chemistry, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, India; Corresponding authors.
Priyanka Saraf: Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra 136 119, India
Jitender Kumar Bhardwaj: Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra 136 119, India; Corresponding authors.
Satish Kumar: Department of Chemistry, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, India
V. Kumar: Department of Physics, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, India
Gaje Singh: Department of Chemistry, Indian Institute of Technology, Ropar, Punjab 140 001, India
Shayoraj: Department of Chemistry, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, India

Journal volume & issue: Vol. 4
p. 100481

Abstract

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Ruthenium (Ru) Dimethylsulphoxide complexes have appeared as a prominent compound among the potential metal-based drug for the cure of cancer. Cancer is marked with the uncontrolled proliferative activity that can be treated with apoptosis inducers. Therefore, in the present study the potentials of ruthenium complexes as an inducer of apoptosis evaluated through appropriate techniques. Two ruthenium (Ru) complexes of composition [Ru II(PyS)2(DMSO)2] (C1) and [RuII(mbtz)2(DMSO)2] (C2) with co-ligands (PySH: 2-mercatopyridine and mbtzH: 2- mercaptobenzothiazole) have been synthesized and examined for their apoptosis inducing activity in ovarian granulosa cells. The biological assays revealed that both the complexes induce various histomorphological, cytotoxic and genotoxic alterations characteristic of apoptosis, within granulosa cells of ovarian antral follicles. Thus suggesting the anti-apoptotic and anti-cancerous activity of ruthenium (Ru) based complexes within granulosa cells of ovarian antral follicles. To the best of our knowledge such studies are scare.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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