Nature Communications (Jun 2022)

The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy

  • Susanne G. van der Grein,
  • Kyra A. Y. Defourny,
  • Huib H. Rabouw,
  • Soenita S. Goerdayal,
  • Martijn J. C. van Herwijnen,
  • Richard W. Wubbolts,
  • Maarten Altelaar,
  • Frank J. M. van Kuppeveld,
  • Esther N. M. Nolte-‘t Hoen

DOI
https://doi.org/10.1038/s41467-022-31181-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Picornaviruses can escape infected cells via packaging in extracellular vesicles (EVs). Here, van der Grein et al. show that the non-structural Leader protein of encephalomyocarditis virus (EMCV) promotes the release of EV-enclosed virus particles and provide evidence for a role of secretory autophagy in this process.